This consists of people using a historical past of liver or kidney disease, pregnant or breastfeeding mothers, and people today with specific professional medical concerns or All those having other medicines [5].
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Shift workers can also have a split dose, though the timing in the doses will depend on the time of every change.
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Metabolism and Elimination The major route of elimination is metabolism (~ninety%), mostly through the liver, with subsequent renal elimination of the metabolites. Urine alkalinization has no impact on the elimination of modafinil.